Atopic dermatitis is an extremely common, pruritic, and frustrating disease to treat in\nboth people and animals. Atopic dermatitis is multifactorial and results from complex interactions\nbetween genetic and environmental factors. Much progress has been done in recent years in terms\nof understanding the complex pathogenesis of this clinical syndrome and the identification of new\ntreatments. As we learn more about it, we appreciate the striking similarities that exist in the clinical\nmanifestations of this disease across species. Both in animals and people, atopic disease is becoming\nincreasingly common and important similarities exist in terms of immunologic aberrations and the\npropensity for allergic sensitization. The purpose of this review is to highlight the most recent views\non atopic dermatitis in both domestic species and in people emphasizing the similarities and the\ndifferences. A comparative approach can be beneficial in understanding the natural course of this\ndisease and the variable response to existing therapies.
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